Antifungal Drugs: Modes of Action and Applications
Antifungal drugs target ergosterol biosynthesis in fungi, disrupting cell membrane integrity. Imidazoles like miconazole and ketoconazole are commonly used for skin infections, while triazoles such as fluconazole treat systemic yeast infections. Allylamines inhibit ergosterol synthesis, with terbina
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Azole Antifungal Agents for Veterinary Use
Azole antifungal agents play a crucial role in treating fungal infections in veterinary medicine. Imidazoles like clotrimazole and triazoles like fluconazole are commonly used for their fungistatic properties. These agents inhibit fungal enzymes, disrupting membrane fluidity and inhibiting cell repl
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Fluconazole: Mechanism, Spectrum, and Clinical Applications
Explore the mechanism of action, spectrum of activity, pharmacokinetics, and clinical uses of fluconazole. Learn about its role in treating various fungal infections, including candidiasis, cryptococcosis, and dermatophytosis, while being aware of resistance issues and dosing considerations.
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HIV Opportunistic Infections and Prophylaxis Overview
Opportunistic infections (OI) are a major concern for individuals with HIV, often accelerating disease progression and causing severe complications. Prophylactic measures such as TB prophylaxis, Clo-trimazole, and Fluconazole are essential to prevent OIs and improve the overall health outcomes of pe
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Single Dose Liposomal Amphotericin in Asymptomatic CRAG+ Patients
Asymptomatic CRAG+ individuals face high rates of failure with fluconazole treatment, leading to meningitis or death. This study aims to evaluate the efficacy, safety, and cost-effectiveness of a single dose of liposomal amphotericin in combination with fluconazole. The prospective cohort study will
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