Understanding Resting Membrane Potential and Excitability in Cells
Explore the concepts of resting membrane potential (RMP), excitability in cells, and the electrochemical basis behind them. Learn about the characteristics of excitable and non-excitable tissues, the factors influencing RMP, and the role of ion distribution in generating the negative charge inside c
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Understanding Strength-Duration (SD) Curve: A Neuromuscular Diagnostic Test
Strength-Duration (SD) curve is a diagnostic test assessing neuromuscular integrity by measuring the relationship between stimulus strength and duration. It helps in electro-diagnosis of peripheral nervous system disorders and evaluates nerve degeneration and regeneration. The curve is obtained by p
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Understanding Cardiac Electrical Activity in Physiology Team's Cardiovascular Block Lecture
Dive into the intricate details of cardiac electrical activity in this lecture led by Physiology Team 436. Explore topics like the cardiac conductive system, action potentials, refractory periods, excitation-contraction coupling, and the effects of autonomic stimulation on heart electrophysiology. D
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Understanding Membrane Potential and Action Potentials in Excitable Cells
Membrane potential, resting potential, and action potentials play crucial roles in the functioning of excitable cells like neurons, muscle cells, and endocrine cells. Voltage-gated channels, depolarization, and repolarization are key processes involved in generating and propagating action potentials
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Understanding Ion Channel Dysfunction in Critical Illness
An intriguing case study presents a young male with weakness and coma in the ICU following pneumonia and sepsis. Nerve conduction results indicated critical illness myopathy and polyneuropathy, along with cardiac abnormalities. Reduced muscle excitability was attributed to a sodium channelopathy. Th
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Understanding Cardiac Action Potential: Ionic Basis and Excitability in Cells
Explore the complex processes underlying cardiac action potential, from ionic equilibrium to resting membrane potential and excitability in cardiac cells. Learn about the critical thresholds, equilibrium potentials, and gradients that regulate the electrical activity of the heart. Discover the intri
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Understanding Neonatal Seizures and Differentiating from Jitteriness
Neonatal seizures are a critical sign of neurologic dysfunction in newborns, with various types such as subtle, clonic, tonic, spasms, and myoclonic seizures. The immature brain's excitability and differences from the mature brain predispose neonates to seizures. Generalized clonic seizures are rare
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Understanding Calcium Homeostasis and Its Importance in the Body
Calcium homeostasis plays a crucial role in various physiological functions, including bone integrity, blood clotting, enzymatic regulation, hormonal secretion, neurotransmitter release, nerve excitability, and muscle contraction. Bones act as a major calcium reservoir, with blood containing 50% ion
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Understanding Membrane Excitability in Action Potentials
Explore the mechanisms of action potentials in nerve fibers, including the all-or-nothing principle, ion channels involved, ion movement, and effects of drugs on action potentials. Learn about accommodation, refractory periods, and consequences of blocking ion pumps on nerve conduction.
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