Successful Collaboration in Environmental Science: A Case Study
A successful collaboration involving government agencies, research organizations, universities, and industry players in the field of environmental science is exemplified through the case study presented. The collaboration led to the adoption of final test requirements related to the fuel additive MMT under the Alternative Tier 2 provisions. The process involved the notification and communication between the EPA and Ethyl, highlighting the constructive engagement between the parties. The collaborative effort encompassed various aspects such as physical, chemical, and biological studies, inhalation studies, dietary studies, and automotive emission studies. The spirit of collaboration continued through the various research activities undertaken, showcasing the importance of cooperation among different stakeholders for impactful scientific endeavors.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author. Download presentation by click this link. If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
E N D
Presentation Transcript
Alternative Tier 2 (Stage 1) A Successful Collaboration among Government, Research Organizations, Universities and Industry Jerry M. Roper, Ph.D. Director, Environmental Science Thursday, January 29, 2009 Final TAP Meeting, Hamner Institutes The symbol is a service mark of Afton Chemical Corporation.
Notification Letter EPA to (then) Ethyl Dear Dr. Lynam: On January 25, 1999, the Environmental Protection Agency (EPA) notified you of a proposed test program requiring emission and health effects testing for the gasoline additive methylcyclopentadienyl manganese tricarbonyl (MMT), in accordance with the Alternative Tier 2 provision of the fuels and fuel additives (F/FA) health effects testing regulation. This letter and its attachments notify you that EPA has adopted final test requirements pursuant to its January 25, 1999 proposal. (EPA letter to Lynam, May 11, 2000)
Cover letter accompanying the Notification Letter Dear Dr. Lynam: In a separate letter today, I notified you of the decision by EPA to adopt specific testing requirements for MMT under the Alternative Tier 2 provisions of the fuel and fuel additive health effects testing regulations. I want you to know that I appreciate the constructive manner in which Ethyl and its contractors have worked with EPA personnel to develop these interim testing requirements. (Letter Oge to Lynam, May 11, 2000)
A successful collaborative effort Universities Research Organizations Industry TAP Government NGOs Sound Science Transparent Process
Collaborative effort preceded Notification Letter Physical, Chemical & Biological Studies Particle size generation Mn solubility in lung fluid Exposure studies Toronto Indianapolis Short-term inhalation studies 14-day in rat w/ 3 Mn species Mntracer elimination Dietary-inhalation studies 3 dietary levels plus inhalation Tracer elimination Olfactory transport studies Blocked/patent nasal passages Automotive Emission Studies Sensitive neuro-endpoints mRNA, protein analysis of brain tissue Investigation of oxidative stress mechanism
Collaborative spirit continued with studies required in the Notification Letter plus those outside the scope of the Letter Inhalation studies in rodents 90-day study young/old/male/female Developmental study Inhalation studies in the monkey 90-day study Rhesus monkey MRI study Sensitive neuro-endpoints mRNA, protein analysis Metabolomics/Biomarker
Collaborative spirit continued to PBPK modeling Gestation and lactation in the rat Adult rat Monkey
Multi-step transparent process EPA review & input Study design TAP review TAP review Draft report Design finalized & study conducted EPA review & input Final report Peer-reviewed journal publications
Kudos & the result of this collaboration Researchers PI, associates, staffers, post-docs, support personnel TAP members animal phase & modeling phase EPA Journals editors, peer-reviewers The Mn Bibliography 50 publications and counting
